Antrocol gel: instruction manual, reviews
Antracol – NSAIDs for topical application. ATC code M02A A10.
Main physico-chemical characteristics: homogeneous transparent gel.
Storage conditions: store the drug should of reach of children at temperature not exceeding 25 ° C. shelf Life: 36 months.
Packaging: tubes of 45 g of gel in each; 1 tube in a cardboard box.
The drug is prescribed:
- when the pain in muscles and joints caused by injuries;
- when tendovaginitis.
- hypersensitivity to the drug;
- allergic reactions of the skin in the treatment fenofibrate, Ketoprofen, tiaprofenic acid, while applying blockers of ultraviolet rays;
- the effect of sunlight, including ultraviolet radiation in solariums, and indirect sunlight;
- photosensitivity in history;
- lesions of the skin injuries, eczema, rashes, skin infections.
Pharmacokinetics and pharmacodynamics
The active substance of the outer Antrocol drug is Ketoprofen. The drug belongs to the group of nonsteroidal anti-inflammatory drugs, derived arylpropionate acid.
Active substance provides analgesic and anti-inflammatory effects, which occurs as a result of indiscriminate inhibition of bradykinin, COX-1, COX-2, inhibition of migration of macrophages, and stabilization of the lysosomal membranes.
The drug has anti-inflammatory and anesthetic effects on the vascular (early) and cell (late) phase of the inflammatory process. Antrocol gel inhibits the aggregation of platelets.
Ketoprofen, when used topically absorbed by the skin, then penetrates into the area of inflammation for a long time and maintains a therapeutic tissue level.
Absorption to the systemic circulation is minimal (5% of dose) and is very slow. The concentration of active substance (50 to 150 mg of Ketoprofen) in blood plasma of eight hours is only 0,08-0,15 µg / ml.
Such content can have on the human body clinically significant effect.
Dosage and method of application
The instructions to the drug is in the box with the cure. Before starting treatment, you should read it carefully. A strip of gel (3-5 cm) is applied to the skin in the desired area and gentle massaging movements rubbed until completely absorbed.
The larger the area affected area, the more gel goes on one procedure. Five-centimeter strip of drug equivalent to 100 grams Ketoprofen.
After rubbing the liniment should immediately wash your hands. The gel can be applied in combination with other medication forms of Ketoprofen (tablets, capsules, rectal suppositories).
The maximum daily dose should not be more than 200mg. Moreover, from the form of medication it does not.
Duration of therapy course determined individually, however, the use of liniment more than 10 days is impossible.
Possible side effects
On the part of the immune system:
- bronchial spasm;
- anaphylactic reactions, including shock;
- asthma attacks.
On the part of the skin and subcutaneous tissue:
- itching, burning, swelling;
- redness, urticaria;
- phlyctenules and bullous eczema, which can propagate and acquire a generalized character;
- contact or bullous dermatitis;
- the syndrome of Stevens Johnson.
Adverse reactions are possible from the digestive tract:
- nausea and vomiting;
- constipation, diarrhea;
- stomach ulcers and bleeding.
From the urinary system disorder renal function, renal failure, exacerbation of chronic renal failure, interstitial nephritis (rare).
There are other possible adverse reactions on the part of the urinary system and the digestive tract. The intensity of these negative effects depends on the amount deposited liniment penetrating ability of the active substance, size of the treated area, skin condition, the duration of the therapeutic course.
Elderly patients are most susceptible to the occurrence of adverse reactions in the treatment of non-steroidal anti-inflammatory drugs.
Overdose and misuse
The levels of Ketoprofen in plasma at external drug penetration is very low, so cases of overdose antrocol gel are extremely rare. The development of systemic adverse reactions is observed only with prolonged use of the liniment on large areas of skin or in high doses.
The main symptoms of the condition, including itching, skin erythema and irritation. In case of accidental internal use of the gel possible side States:
- dizziness, drowsiness;
- nausea and vomiting;
- the epigastric pain.
High doses of Ketoprofen can cause:
- acute renal failure;
- instability of blood pressure;
- gastrointestinal bleeding.
Treatment should be symptomatic and aimed at maintaining basic body functions. It is useful gastric lavage and taking several tablets of activated charcoal.
Treatment Antrocol gel in pregnancy and lactation
For the study of the drug, scientists conducted experiments on rodents. The results of these studies demonstrated that animals were not observed embryotoxic and teratogenic effects. Slight embryotoxic effect was seen in experiments on rabbits. Doctors explain its toxicity to the rabbit.
Because the safety of Ketoprofen in relation to pregnant women was not supported by any research (they simply did not), doctors will not prescribe Ketoprofen expectant mothers, especially during the first and second trimester of pregnancy.
Ketoprofen and all other inhibitors of prostaglandin synthesis provoke toxic lesion of the heart, pulmonary system and kidneys of the fetus.
However, the instructions for use not recommended to be treated with the drug in the third trimester of pregnancy, as the mother, and the fetus may develop prolonged bleeding.
Products of Ketoprofen can be detected in breast milk, and this factor does not depend on the dosage forms (tablets, gel, rectal suppositories). For this reason, Antrocol do not prescribe to breast-feeding women.
Children under 15 years of age the drug is also contraindicated.
Other recommendations for use
The gel is designed for external use. If the time of application of the drug for some reason skipped the next procedure, a dose of gel should be redoubled. After application immediately wash your hands to avoid getting medication in eyes and mouth.
If there is negative reaction on the part of the skin, treatment Antrocol gel should be discontinued. This includes skin reactions in parallel using products containing in its composition of octocrylene. This substance is a component of many hygiene products:
- the shaving gels and shower;
- liquid for removing makeup;
- rejuvenating masks and creams;
- a hairspray.
After the appearance of any skin reactions therapy Antrocol gel should be discontinued immediately. You cannot use this product on open wounds, acne and other inflammation of the skin, mucous membranes, avoid contact with eyes.
Photosensitivity is a serious skin reaction that can develop if the skin is coated with a liniment comes under the action of ultraviolet rays (even in the foggy day or in the Solarium).
To avoid such negative manifestations during the period of treatment and during the next two weeks shouldn’t be outside with exposed skin. For this reason, during this period, not to visit the Solarium.
When applying the product it is advisable to use medical gloves, which will help to avoid irritation of the skin.
External use a large number of liniment may exert a systemic effect, in particular bronchial asthma and a manifestation of hypersensitivity. To avoid these side effects, reactions of photosensitivity and contact dermatitis should never exceed the dose that the instructions to the drug. There are few cases of side effects in the kidneys.
If the patient in addition to joint disease are pathologies of the cardiovascular system, kidneys and liver, treatment with Antracol should be performed with extreme caution. Not less carefully it is necessary to monitor the condition of those patients, which in parallel with Antracol gel taking lithium salts, anticoagulants and diuretics.
Because the liniment contains in its composition of ethyl alcohol, the drug cannot be used in close proximity to the open flame.
Evidence that Antrocol can inhibit the reaction rate when driving a car or work with complex mechanisms to date there.
Interactions with other medicines
Due to the fact that the concentration of active substance in plasma is very low, symptoms of interactions with other medications can occur only during prolonged treatment and the use of large doses.
Antrocol enhances the effect of the following drugs:
- anticoagulants, including acetylsalicylic acid;
- any nonsteroidal anti-inflammatory drugs group;
- oral hypoglycemic drugs;
Simultaneously with Antracol gel is not recommended to use other external agents (creams, ointments, gels, rubbing), which contains Ketoprofen and other NSAIDs.
Reduces the effect of diuretics, mifepristone and any antihypertensives.
Increased toxicity of cardiac glycosides, methotrexate, lithium salts.
Between the therapeutic course of mifepristone and the start of treatment with Ketoprofen must pass eight days – at least.
Use of gel Antrocol associated with pain in the joints, and the video in this article, popular will tell, what else can you do when pain syndrome.