The torasemid diuretic: properties, mechanism of action
To get rid of puffiness, symptomatic manifestations of disease, such as renal, hepatic or cardiac failure, to help diuretics. Among other highly considered loop diuretics of the type to which applies «Torasemid». Medication is prescribed to patients with high blood pressure, nephrogenic diabetes insipidus and to prevent kidney stones in idiopathic hypercalciuria of. Diuretic has a long list of contraindications and side effects, so to prescribe the drug and monitor the condition of the patient should the attending physician — this guarantees the desired result and prevent unwanted consequences of self-treatment.
Properties diuretic «Torasemid»
«Torasemid» acts in loop of Henle (ascending portion of the nephron loop) and prevents reabsorption — the reverse absorption into the bloodstream of the ions of minerals such as chlorine and sodium also increases the excretion of potassium. This Association begins to operate after about 1 hour, the maximum diuretic effect is achieved over the next 2-3-chasov, and after 4 hours the drug is eliminated from the body almost completely. In people with abnormalities in the liver or kidney, heart failure longer the process half-life of metabolites «of Torasemid» (intermediate products of metabolism in living cells), but the accumulation of substances in the body unlikely. However, it is important to remember that «the Torasemid» and its metabolites in proceedings hemofiltration or hemodialysis almost not displayed.
Mechanism of action
From the mechanism of action, localization in the nephron (the structural and functional unit of the kidney) and the physico-chemical properties of diuretics depends on the degree and duration of their effect on urine formation, ability to inhibit reabsorption. Diuretic «Torasemid» due to reversible binding with cotransporter — protein, localized at the apical membrane of the cells of the parts of the nephron and the division of the loop of Henle, limits or completely inhibits the resorption process. Thus, under the influence of drugs prevent the reverse suction of fluid and substances dissolved in it, increasing urine output and thereby decreases swelling.
Drugs on the basis of torasemid
Preparations on the basis of torasemid do not differ in composition. The whole difference consists in the number of active substances, indications and manufacturer. But replacing the prescribed medicine a analogue without consulting a doctor, and based only on information of the user-liner, is not recommended. This may adversely affect the results of therapy or seriously worsen the condition.
- «Diver» (table. No. 10) — 5; 10 active ingredients;
- «Torasemid Canon» (table. № 20, № 60) — 5;
- «Torasemid Sandoz»: table. 2,5; № 20, № 100 — 2,5; table. No. 20 No. 100 — 5; tabl. No. 20 No. 100 — 10; table No. 20 No. 100 — 20; table. No. 20 No. 100 — 50; table. No. 20 No. 100 — 100; table. No. 20 No. 100 — 200 active substances;
- «Trigram» (table.; № 10, № 30) — 2,5; 5; 10;
- «Tripas»: tabl. No. 30 — 5; table. № 30, № 50, № 100 — 10; table. No. 10, No. 30 — 200 active substances.
A method of receiving and testimony
The tablets should be taken without chewing and with sufficient amount of water, preferably at the same time of day, before or after a meal. The drug is indicated in patients with symptomatic swelling in heart, renal insufficiency; essential hypertension (chronic hypertension). During the course of treatment «Torasemid» it is important to control the level of uric acid, minerals and electrolytes, residual nitrogen in the blood. If necessary to adjust the dosage.
|When taking medications can result in unpleasant soreness. For example, you may get sick or dizzy; sleepy; be dizziness to fainting; in muscles of legs and hands can be felt weakness, cramps or tingling; vision problems and hearing.
Heart on the drug can respond to arrythmia, arrhythmia or tachycardia, acute cardiovascular failure, collapse. Circulatory system — the sudden decrease in pressure, thrombosis, severe bleeding from the nose. In the blood may increase the sugar level, cause anemia.
Vomiting, nausea, abdominal pain, diarrhoea, flatulence may signal the gastrointestinal tract, pancreas, gallbladder, liver. In addition, you may experience different kinds of dermatitis, itching, allergic reaction to the sun. A natural consequence of medication will be various changes in the processes of urine formation and urination. Genitourinary system men can respond to reduced potency.
|The use of the drug is prohibited for women during pregnancy and lactation, children under 18 years of age. Should abandon the use of medication for people with allergies to sulfonamides, severe hepatic and renal nedostatochnosti, with low content of potassium, sodium, and increased levels of uric acid in the blood, dehydration and hypovolemia, defect or heart failure, glycoside intoxication, accompanied by arrhythmias, in violation of rochevilaine.|