Glucophage diuretic or not: indications for use
Often, the medicines intended for the therapy of diabetes mellitus, use among dieters. In this context many people wonder, «Glucophage» diuretic or not? However, despite the ability of this drug to reduce weight, it is not a diuretic and doctors-endocrinologists don’t recommend yourself to use it for weight loss because of wrong regimen of medication can lead to dangerous side effects.
Pharmacological group and action
Described medicine refers to hypoglycemic drugs for oral consumption of the group of biguanides. Medicines in this category are aimed at reducing blood glucose levels, and are used for the treatment of diabetes. In addition, the drug increases sensitivity to insulin, helps reduce production of glucose in the liver and its utilization in muscles. The main direction of medications the group of biguanides treatment of 2nd type diabetes mellitus.
Hypoglycemic drug could lead to normal weight, which is why it can be assigned to the relevant specialists for patients with excess body weight. Medicine «Glucophage» is adsorbed in the gastrointestinal tract and reaches its maximum action after 2.5 hours after drinking the dose. Duration the highest concentration in the blood reaches 7 hours. Components of the drug in the most part excreted by the kidneys, and the rest of the intestine.
The composition and form of issue
In the pharmacy networks can be found «Glucophage» in the form of tablets, each of which contains:
- food emulsifier Е572;
- Metformin hydrochloride.
Pills stocked in blisters of 10 to 20 pieces and placed in cardboard boxes 2-3 blister cell. Each pill contains 500, 850 and 1000 mg of active substance. Manufacturers produce tablets 500 and 850 mg, white, round shape, with bulges on both sides. Pills «Glucophage» 1000 mg different oval form and engraved on one side is «1000». All tablets coated film and have a cross-section.
Indications for use
Assigned to the described pharmacological agent in combination with insulin for the treatment of severe obesity. Are particularly encouraged to apply «Glucophage» patients with diabetes type II at an elevated body weight. Effective drug for prevention of diabetes with existing prediabetes. It is worth considering that the dosage is appointed solely by the attending physician, after the examinations and the evaluation of severity of course of disease.
To avoid unwanted effects after taking «Glucophage», it is not recommended to use it in the following cases:
- aggravation of various diseases;
- renal and hepatic dysfunction;
- the increase in serum lactic acid;
- surgery and injury;
- breastfeeding and pregnancy;
- alcoholism and alcohol poisoning;
- age 60 years;
- hypersensitivity to the components.
In the use of «Glucophage» you may experience the following unwanted effects:
- the development of lactic acidosis;
- the deterioration of the absorption of cyanocobalamin;
- a violation of taste sensations;
- felt sick;
- pain in the abdomen;
- poor appetite;
- burning sensation, rash and redness of the skin;
- disruption of the normal functioning of the liver.
Before you start treatment pharmacological agent «Glucophage», it is necessary to study its interaction with other drugs. For example, it is not recommended to use this medicine concomitantly with the drug «Danazol», as this can lead to the development of a sharp increase in the level of glucose in the blood. If such a combination is unavoidable, the patient should monitor glucose levels and adjust the dosage. Greater danger lies in the combination of «Glucophage» with «Chlorpromazine», the latter greatly improves glycemia and reduces the excretion of insulin. Concomitant use with diuretics, the main impact is in the loop of Henle, increases the risk of lactic acidosis due to disorders of the kidneys.
Method of application and doses of Glucophage as a diuretic
The reception of medicine «Glucophage» is solely at the prescription of the medical doctor in their assigned dosage. Therefore, it is recommended to reduce body weight, in the absence of diabetes, take 500 mg two or three times a day. Pills do not chew and drink in the process meal or directly after a meal. The duration of the therapeutic course is 3 months, re can be performed only after 3 month break. In the use of diuretic medications is prohibited to refuse to eat for a long time, knocks need to consume not less than 1000 kcal. Absolutely contraindicated drink alcohol-containing beverages, engage in increased physical exertion and challenging sports training. In parallel with taking «Glucophage» is not recommended to take diuretics and vitamin complexes, which is iodine.
Failure to comply with these doses there is a risk of lactic acidosis. Today the antidote to the medicine, does not exist. In case of overdose, cancel the drug and symptomatic treatment should be done in a hospital with the possibility of determining the concentration of lactic acid. Reduce the level of lactate in the body with the help of extrarenal blood purification.
In the process of using «Glucophage» patient conduct regular monitoring of indicators of blood. If necessary, surgical intervention or during pregnancy patients are transferred to insulin. In the treatment of «Glucophage» it is strictly forbidden to drink alcoholic beverages and taking medication with a diuretic effect.
Storage conditions and shelf life
Released drug «Glucophage» from pharmacies by prescription. Pharmaceutical preparation to be stored away from children and sunlight at temperature not exceeding 25 degrees Celsius. The shelf life of the medicine is 5 years and after this time to take the medicine is contraindicated.