Diuretic Losartan: indications, side effects
Pharmaceutical agent «Losartan» is used for lowering blood pressure, but few people know that this drug possesses diuretic effect. The drug effectively removes excess salts of sodium and uric acid from the body while retaining potassium, which are necessary for the normal functioning of the heart muscle. Take «Losartan» the appointment of specialized professionals, in strict compliance with the assigned treatment regimen.
Produced the drug «Losartan» form of coated tablets. Each tablet contains losartan potassium, which is an active component and such additional substances:
- food emulsifier Е572;
- maize starch;
- dietary Supplement Е1518;
- purified talc;
- milk sugar;
- food dye E172;
- food additive E171.
Pharmacology and pharmokinetics
Drug «Losartan», providing a diuretic and hypotonic actions, used to reduce high blood pressure and normalization of body fluids. It has been noticed that this medicine with extreme physical exertion improves stamina and prevents thus of myocardial hypertrophy. After penetration of components of drugs in his blood the main action aimed at the normalization of HELL, is reached after 6 hours and lasts for days, gradually declining. The maximum effect of «Losartan» develops 3-6 weeks after adopted first dose. The drug is well absorbed and reaches its highest concentration in about an hour. After oral consumption of the time for half-life it takes about 2 hours. Displays the drug to its active metabolite through urine and bile.
Indications diuretic «Losartan»
It is recommended to use the drug «Losartan», which has a diuretic effect, with such pathologies:
- dysfunction of the cardiac muscle of chronic form;
- hypertrophy of the left ventricle;
- high blood pressure (to prevent stroke);
- diabetes mellitus type II, dealing damage to the kidneys;
- high levels of protein in urine.
Should abandon the use of «Losartan» during pregnancy, children whose age is under 18 years of age, with hypersensitivity to components of the medication, as well as for the following pathologies:
- renal failure severe form;
- intolerance to the monosaccharide transmitted by heredity;
- deficiency in milk sugar.
The admission of pharmaceuticals «Losartan», which has a hypotensive and diuretic action, dangerous to the patient the appearance of the following undesirable phenomena:
- increased fatigue;
- sleep disorders;
- a violation of taste receptors;
- congestion of the sinuses;
- memory disorders;
- dryness of the skin of the skin;
- frequent loose stools;
- pain in the back;
- increased body temperature;
- rashes and itching on the skin;
- sore throat;
- swelling of the tongue, face, pharynx;
- ringing in the ears.
In the case of non-compliance doctor doses, was seen in cases of overdose. To specify which can:
- drastically reduced blood pressure;
Method of application and dosage
Drug «Losartan» is intended for oral administration. The pill 1 time per day regardless of eating. For the treatment of hypertension taking 50 mg/day. In some cases, at the discretion of the attending physician, the dosage may be increased to 100 mg, divided into 2 doses. When the cardiac dysfunction is recommended to take 12.5 mg 1 time per 24 hours. According to indications, the dosage may be increased with a week interval to 25 mg and 50 mg per day. Because «Losartan» has a diuretic effect, while consuming it with diuretic drugs, which are taken in high doses, a single dose is 25 mg/day.
Before taking the «Losartan», providing a diuretic effect, it is necessary to get acquainted with the peculiarities of its use. Thus, patients with renal disease recommended treatment in the least possible effective dose. Patients with renal dysfunction receiving «Losartan» dangerous deterioration of renal function with increasing level of potassium in the blood. Accordingly, in use of the described medication with a diuretic and hypotensive effect, it is necessary to regularly monitor the content in plasma potassium.
Serious interaction «Losartan» with other drugs have been identified. However, it should be careful when sharing the use of this medicine with other drugs that have a diuretic effect, as it can lead to the development of hyperkalemia, which can adversely affect the patient’s condition. In the combined reception of «Losartan» with pharmaceuticals that are designed to lower HELL, their effects are mutually enhanced. Overall this is an excellent tool for the treatment of hypertension, which can be used both independently and in combination with other medications.