Diuretic gidrokhlorisiazit: indications for use
Effective diuretic «gidrokhlorisiazit» is widely used for the treatment of kidney conditions and heart failure, accompanied by edema, due to its ability to hold blood magnesium, potassium and calcium, and lower blood pressure. However, before taking this thiazide diuretic, you should consult with an expert, as it has a number of contraindications, if neglected, there is a risk of side effects.
Release form and composition
Produced «Hydrochlorothiazide» in the form of tablets which are placed in the plate with the cells for 20 pieces. Each carton contains 1 disc. On the pharmacy shelves you can find packs of 2 plates for 10 tablets. In the composition each tablet contains:
- gidrokhlorisiazit, which is the active component;
- Supplement Е572;
- lactose monohydrate;
- starch from potatoes;
Pharmacological effect and group
Medicine «gidrokhlorisiazit» refers to the diuretic group (ATC code: С03АА03). Is a diuretic expectancy effects on the body. This thiazide diuretic when injected into the blood prevents the absorption of ions of magnesium, sodium, potassium, water and chlorine. Is increased production of urine after 1-2 hours, the effect lasts from 6 to 12 hours. Reduction in activity occurs with a decrease of speed glomerular (glomerular) filtration and stops completely when the value is not less than 30 ml/min, Thiazides do not affect the HELL that is the norm, reduce excretion of calcium in the urine, which reduces the risk of kidney stones.
The medication is absorbed from the gastrointestinal tract is not completely the maximum dose in plasma is determined after 3-5 hours. For half-life 7-14 hours required. The drug is not broken down in the liver and exported in unchanged form through the kidneys is almost 95%. Passes into breast milk and the placenta.
Indications for use
Pharmaceutical preparation «gidrokhlorisiazit» is assigned to the relevant technician in the following cases:
- high blood pressure, congestive heart failure, accompanied by swelling;
- if the patient was diagnosed with cirrhosis of the liver with ascites;
- for the treatment of renal dysfunction and other kidney conditions;
- at elevated eye pressure subcompensated form;
- as the prevention of the development of kalcevich kamneobrazovaniu;
- patients with diabetes insipidus.
Application and dosage
Diuretic «gidrokhlorisiazit» is available in the tablet form intended for oral administration. Taking a drug in the process of meal or after it. While the tablets are swallowed whole without chewing. A specific schedule of the dosage and duration of the therapeutic course depend on the severity of course of disease and is calculated solely by the doctor. To eliminate edema in adults diuretic «gidrokhlorisiazit» is assigned 1 to 4 tablets a day. In children the drug is recommended to be taken from the calculation of 1-2 mg per 1 kg of weight of the baby. The long-term use of diuretics it is important to take short breaks.
Professionals will not prescribe a diuretic medication «gidrokhlorisiazit» sick, if they have one of the following pathologies:
- severe hepatic or renal failure;
- hypersensitivity to the drug;
- violation of receipt of urine in the bladder;
- diabetes, which is controlled;
- chronic adrenal insufficiency;
- hypercalcemia, hypokalemia.
After using a diuretic «gidrokhlorisiazit» can receive the following undesirable phenomena:
- gag reflex, nausea;
- palpitations, orthostatic (when changing the position of the body) reducing the pressure;
- increases blood sugar and decreases the number of platelets;
- increases concentration in plasma sodium, calcium and potassium;
- there is a regular fatigue, weakness and dizziness;
- on the skin can be signs of an allergic reaction.
Overdose diuretic «gidrokhlorisiazit»
If you take diuretic medications «gidrokhlorisiazit», exceeding prescribed dosages, can cause the following symptoms:
- General malaise;
- felt sick;
- violation of salt exchange;
- the aggravation of diseases of the joints.
Before using a diuretic «gidrokhlorisiazit», it is necessary to study its interactions with other medicines. For example, in the use of this medication by indirect anticoagulants increases the diuretic effect. The combination of tricyclic antidepressants, ethanol, vasodilators with «Gidrohlortiazidom» enhances the hypotensive effect of a diuretic. When co-administered with cholestyramine the inhibition of absorption of thiazide diuretics, which significantly reduces their impact on the body.
The conditions of storage and sale
Released the pharmaceutical preparation «gidrokhlorisiazit» strictly by prescription. Medication shall be stored in original packaging for 5 years in a room where temperature is in the range of 15-25 degrees Celsius. After the expiration date to take a drug is contraindicated, and it is recyclable.
Therapy with diuretic should be monitored by specialists. The daily dosage should be divided into several intakes in such a way to minimize all the inconveniences that follow after taking a diuretic. In the treatment process «Gidrohlortiazidom» it is important to comply with diet and medication use, adhering to time schedule.