Diuretic aldosterone antagonist: Spironolactone, Veroshpiron, Aldactone
Diseases of the kidneys and the entire urogenital system involve the use of diuretics. They excrete excess fluid and salt. «Spironolactone», specialists prescribe a diuretic to prevent a sharp decline in the level of potassium and magnesium in the blood. This drug belongs to the group of aldosterone antagonists, which contribute to normal pressure, while maintaining the balance of the elements in the body.
The effectiveness and indications for use
The main drugs of the group of aldosterone antagonists directed to arrest the body of potassium and magnesium. However, they do not inhibit the excretion of sodium and excess fluid. Prescribe these drugs providing a higher level of the hormone aldosterone. Therefore, they are effective for patients with heart disease, as they help normalize blood pressure and improve health of the patient. Antagonists of aldosterone eliminate arrhythmia, tachycardia and fibrillation.
Types of diuretics aldosterone antagonists
There are two types of diuretics aldosterone antagonist. The first of them is non-selective. It relates to «Spironolactone». Diuretics of this type interact not only with receptors, producing aldosterone, but also with those that produce progesterone and androgen. The second type of drugs is selective. We are talking about «Eplerenone» which interacts only with the receptor, producing the hormone aldosterone. Young people assign it a selective diuretics, as they do not affect the production of sex hormones.
Method of application and doses
The dosage of the drug must appoint only specialist. At the beginning of treatment is credited with a minimal amount of active substance. Thus it is necessary to organize weekly blood tests to monitor biochemical parameters. A day the patient takes the drug from 2 to 4 times. While taking aldosterone antagonist should limit the use of other means for control of potassium in the blood. Neglect of this rule causes complications and deterioration of the General condition of the patient.
Today potassium-sparing diuretics has developed a bit of funds. The main and often appoints are «Spironolactone», «Verospiron», «Aldactone» and «Triampur». Next, let’s consider the main characteristics and properties of these drugs and recommended dosage for different patient groups.
This tool is responsible for a decrease in the yield of potassium and magnesium with the urine. It has a diuretic effect, allowing you to assign it in diseases, accompanied by edema. Available in tablet form. For best absorption in the intestinal wall, it is recommended to take the drug during meals. The result from the drug «Spironolactone» occurs 3-5 days. The dose and frequency of taking the pills is determined by the doctor based on the laboratory results of urine and blood. The average duration of use is 3 weeks. Use by pregnant women is possible only in the 2nd and 3rd trimester. During lactation it is necessary to consider that through the milk to the child also gets. Their own to begin taking «Spironolactone» it is impossible, as it leads to imbalance of substances in the body and deterioration of the patient.
Diuretic results in reduced excretion of potassium from the body, thus stimulating the release of fluid and sodium. The primary substance which exerts this effect is spironolactone. Assigned «Verospiron» as a separate medicament, or in combination with other drugs. To speed up the action it is taken inside while eating. Components of the drug tend to be absorbed into the placenta and enter breast milk. Therefore, during pregnancy and during lactation should stop taking «Verospiron». Simultaneous use with other drugs is possible only after consultation of the doctor as a diuretic interacts with many components of medicine. For the first time after the start of treatment, ban on driving and work requiring quick reactions.
A diuretic refers to a group of aldosterone antagonists. In addition, has the property to lower blood pressure. Available in the form of tablets, coated. This form of production helps to maximize the absorption in the intestine. The effect of taking «Aldactone» comes on the 4-5th day of treatment. The initial dose is 100 mg/day. Further, the number determined by the physician based on the results of blood and urine tests. During pregnancy and lactation can be used «Aldactone» only when absolutely necessary. Simultaneous administration with other diuretics allowed if doctor.
This tool is considered to be combined, that is, having kalisberegauschee, diuretic and hypotensive action. The main active ingredients are triamterene and hydrochlorothiazide. The effect of the admission occurs after 2 hours. Prescribed drug edema and reduced blood pressure. Make «Triampur» after eating, squeezed small amounts of liquid. The dose in the initial stages of the disease is 2 tablets a day. Further, the dosage and frequency is determined by the doctor. Long-term use should periodically blood tests.
Aldosterone antagonist — weak diuretics, but it has a number of contraindications. The first of these — pregnancy, especially the early line. Appointment on the 2nd and 3rd trimester possible only if the positive effects on the body of the mother outweighs the negative on the child. During breastfeeding the intake should be stopped, as the active ingredients of diuretics are absorbed in breast milk. The following contraindication is the increased level of potassium in the blood, and creatinine level. In renal and hepatic nedostatochnosti forbidden to use diuretics. Another reason to abandon the aldosterone antagonists — Allergy to components of preparations.
Incorrectly calculated the dosage or self-medication can cause side effects from the use of diuretics. We are talking about hyperkalemia, that is a sharp increase in the level of potassium in the blood. This disease leads to arrhythmias, muscle paralysis and cardiac arrest. To prevent this will help the regular monitoring of potassium level in the blood. Common side symptoms include nausea, culminating in vomiting, diarrhea, and dizziness. Men may erectile dysfunction, and women — disruptions in the menstrual cycle. To minimize the side effects to use a diuretic you need under the careful supervision of a specialist.