Bisoprolol diuretic or not: indications, application
In the treatment of hypertension along with diuretics use «Bisoprolol», but many are interested in. is it a diuretic? Medication from the group of selective beta-blockers. Lowers blood pressure and has anti-ischemic effect is not due to the diuretic effect, and due to selective blockade of beta—receptors. «Colour» controls the frequency of heart beats.
Comparison of Bisoprolol with other diuretics
The researchers compared the effects of «Bisoprolol» on the body with hypertension and the efficacy of other medicines to lower the pressure, including from the group of diuretics. It has been proven that this highly selective beta-blocker on a number of indicators superior to diuretic antihypertensive funds. Was mapped the effects of 10 mg «Bisoprolol» and the combination of 50 mg of «Gipotiazid» («Dihlotiazida») from 5 mg «Amiloride» in two parallel groups of patients. After 30 days of therapy greater the blood pressure decreased in patients who had received «Bisoprolol». More than 88% of the patients in this group lower, the diastolic pressure decreased to 90 mm Hg and less. article In the group of patients who were treated with diuretics, this figure was achieved in 23.5% of subjects.
Were compared with a diuretic «Chlorthalidone». After a course of treatment (28 days) decrease in diastolic blood pressure less than 90 mm Hg. article recorded in 82% of patients who took «Bisoprolol» and 84% of subjects who took «Chlorthalidone». In addition, the «Chlorthalidon» (diuretic drug) more often caused adverse reactions: there were significantly reduced number of potassium ions in the blood, level of uric acid in plasma, on the contrary, increased.
Indications for use
coronary heart disease;
- arterial hypertension;
- congestive heart failure;
- stable angina.
- pulse less than 50 beats per minute (bradycardia);
- a number of cardiac abnormalities;
- hypersensitivity to beta-blockers;
- severe hypotension (increased systolic blood pressure below 90 mm Hg.St.);
- severe diseases of the respiratory system;
- serious circulatory problems in the extremities;
- taking anti-depressants.
- «Bisoprolol» do not appoint women during pregnancy and breastfeeding, persons under age 18.
Method of application and doses
«Bisoprolol» taken one in the morning before eating. Not to break with the usual life style as when taking diuretics. Pill to swallow, without chewing, drinking water. When the diagnosis of arterial hypertension, coronary heart disease, the recommended amount of the drug — 0.5 g Daily dose if necessary, can be raised up to 0.1 g. the Maximum dose of 0.2 g per day, when expressed, disfunktsii kidney and liver — 0.1 g for the patient. Available in the form of coated tablets of 2.5, 5, 10 mg in packs of 30, 50, 100 pieces. The exact dosage and the drug is carried out only by the attending physician.
Adverse reactions side effects
Despite the extensive list of side effects, when therapy «Bisoprololum» they are less common, undesirable reactions occur in less in comparison with drugs of the group of beta-blockers older generation or with a diuretic effect. Patients had the following symptoms:
- Weakness, fatigue, headaches and dizziness, sleep disorders.
- Can disturb sensitive limbs.
- Irritability, dryness of eye, dryness of the mouth.
- Nausea, indigestion.
- The deterioration of the conduction of nerve impulses in the heart muscles and the weakening of their contractility, sinus bradycardia, blocking the activity of the heart, arrhythmias, the risk stops, increased symptoms of chronic heart failure (breathing problems, swelling of the legs), arterial or orthostatic hypotension, vascular spasms.
Overdose and withdrawal symptoms
- acute heart failure;
Dose should be reduced for patients older than 55-60 years old, and if there growing slow heart rate less than 50 beats per minute, and by reducing systolic pressure below 100 mm Hg, severe violations of the liver and kidneys. In depressive States caused by the use of blockers, the treatment should be stopped. The abolition of «Bisoprolol» carry out gradually, reducing the dose by 25% every 3-4 days. Otherwise, increases the risk of severe arrhythmias, heart attacks.
Interaction with other drugs
Appointing «Bisoprolol», the doctor is obliged to consider the medication given to the patient. In combination with antihypertensive drugs, diuretics — diuretics, or «Clonidine» («Clonidine»), «Hydralazine», «Nifedipine» is enhanced by lowering blood pressure. Anti-arrhythmic means for parallel reception of «Bisoprolol» can increase the risk of manifestations of bradycardia. The decrease in the activity of the Central nervous system exacerbate neuroleptic drugs, alcohol, some antidepressants, hypnotics, sedatives, taken together with the «Bisoprololum». Asteroidy hormonal drugs to weaken its effect on reducing blood pressure. If necessary, General anesthesia, gradually reduce the dose and stop taking «Bisoprolol» two days before a planned surgery.
Use features, precautions
Taking «Bisoprolol», you need to be especially careful driving transport, working with potentially hazardous machinery and tools, engaging in activities that requires high concentration of attention.
Check the condition of the patient, treating the «Bisoprololum», involves the monitoring of heart rate and blood pressure. Patients with a diagnosis of diabetes check the level of glucose concentration in the blood. In people older than 55-60 years examined the kidneys. Tests conducted every 3-4 months. Before the use of «Bisoprolol» patients with diseases of the bronchi and lungs is to be examined respiratory function. Persons using contact lenses should take into account the possible reduction in natural moisture eye. The shelf life of the drug indicated on the packaging. Store in a dry, dark place.