Systemic lupus erythematosus: what is this disease in women
Causes of lupus and its treatment
Red lupus medicine while not fully studied, and all because this kind of disease is characterized by inflammatory processes that can occur in different organs, sometimes at the same time. Exactly where will be celebrated following the inflammatory process, is very difficult to predict, in addition systemic lupus erythematosus occurs with periods of exacerbation and remission.
What disease is unable to talk in detail only doctors, patients don’t always understand what’s going on with their body. If to explain in simple language, what is lupus, we can say that it is a chronic autoimmune disease characterized by a malfunction of the human immune system. The body produces antibodies to its own tissues, organs, and joints, slowly destroying them.
- The causes of the disease
- Symptoms of lupus
- The symptoms of the disease depending on the affected area
- Treatment of lupus
- Complications of the disease
The causes of the disease
Systemic lupus erythematosus, as noted above, is not fully understood, therefore, exactly to say, which causes the disease it is impossible. There are a number of predisposing factors that can cause the symptoms of SLE. The development of the disease plays an important role genetic predisposition to systemic lupus erythematosus. If one of the parents suffered from lupus, then the probability that systemic lupus erythematosus to occur and the child is 5%, if one of the twins got sick, then the probability that the symptoms of lupus will occur in the other 80%.
The causes of the disease can be associated with the violation of hormonal background, according to numerous studies, women with SLE noted an increased amount of estrogen and prolactin. This files most often have symptoms of lupus during pregnancy or after birth, that is, when there is a hormonal surge.
There is a viral theory of disease development, it is based on the fact that almost all people with systemic lupus erythematosus found a virus Astana Barra. Some scientists believe that the disease can cause gene mutations. Identified a group of genes, which provokes the immune strength of the person, whereby the body cannot fight off foreign agents or produces an increased amount of phagocytes. These components of the immune system make their own cells «foreign» and destroying his internal organs and joints.
It will be interesting to see what lupus erythematosus in men develops in 5 times less often than women, black people are more disposed to the disease. Among patients most people from 15 to 45 years, among children the disease does not occur.
Despite the high level of modern medicine, doctors have to be considered with all aggravating factors that can cause disease, and the process of elimination to find the true cause of systemic lupus erythematosus SLE.
Symptoms of lupus
Lupus erythematosus what is progressing, first manifested in the skin, marked a characteristic rash. Skin changes peel and resemble psoriatic plaques only, in most cases, painted in red color and severely swollen. At the edges of plaques visible dilated capillaries and the vascular mesh. Can develop sores around the mouth and on the mucous membranes of the lips, they are very itchy and cause discomfort.
Systemic lupus erythematosus is not confined to any one system or body, usually it affects the entire body, respectively, the symptoms manifested in the disease process will be diverse. Most often, patients report:
- pain in muscles and joints;
- swelling of the skin;
- increased fatigue;
- the kidney failure;
- psychosis, paranoia, hallucinations;
- puffy eyes;
- cardiovascular disease;
- paroxysmal bruising fingers;
- painful breathing;
- hair loss;
- stomach ulcers and other disruption of the digestive system;
- enlargement of lymph nodes.
It should be mentioned that systemic lupus erythematosus affects the nervous system, it can occur in migraine or ischemic stroke, cerebral ataxia, and stroke.
Lupus everyone develops with different intensity. If the disease develops acutely, the detailed clinical picture is marked for 2 months. If time does not begin treatment signs of systemic lupus erythematosus, throughout the year people will die.
Subacute course of the disease is characterized by such striking manifestation of symptoms and signs of lupus developing over the years. Also note the chronic manifestation of the disease, the symptoms can develop gradually over many years. For their relief, as a rule, use the minimum dose of drugs. Symptoms may go away, but then reappear with greater intensity. Provocateur exacerbation of the disease, as a rule, exposure to the sun.
The symptoms of the disease depending on the affected area
If you have a disease like lupus erythematosus symptoms may vary depending on the organs that are affected first. For example, joint and muscle syndrome is manifested in 80% of patients. It can be characterized by fever, pain in the small joints — the ankles, phalanges, wrist, rarely in the muscular region. Sometimes muscles atrophy, occur subluxation, palpation muscle area very tense and painful. Articular syndrome may be reflected in such diseases as arthritis and osteoporosis, which develop on the background of a General decline of immunity.
With the defeat of the lungs, there is pain in breathing, cough with sputum and shortness of breath strong even in a resting state. Don’t shy away from the disease and kidneys, it causes so-called volcano jade. Interestingly, pain in the kidneys, the patient does not feel, fibrotic changes that occur in the internal organs, appear only in swelling of the ankles and the skin around the eyes.
Lupus disease causes many disorders in the circulatory system — anemia, leukopenia, thrombocytopenia, it increases the ability of a person to blood clots.
Options for the development of the disease and the symptoms so much that doctors don’t undertake to predict the outcome of treatment. In therapy there will be many medical professionals, because both can manifest lesions of different systems, and to give preference to any one and treat only kidney, for example, forgetting about neuralgia, not. According to statistics, with timely treatment survival of 78% of patients.
Treatment of lupus
Before you begin to treat the disease of systemic lupus, it is necessary to confirm the diagnosis. For this, the doctor sends the patient for such studies:
- x-rays of the lungs and joints;
- functional test of the kidneys;
- ECG of the heart;
- magnetic resonance imaging and computed tomography.
Based on the obtained data, will be assigned a comprehensive treatment plan. Selection of drugs is carried out depending on the patient’s age, individual characteristics of his organism and the nature of the symptoms.
Treatment of systemic lupus erythematosus, tend to spend drugs of three groups: corticosteroids, tsitostatikov and non-steroidal anti-inflammatory drugs (Naproxen, Anaprox, Plugins).
Articular syndrome treated with Chloroquine, Atabrine, Delagila. Patients with articular syndrome need vitamin D and calcium, as the disease destroys cartilage and bone. Articular syndrome requires correction of the physical, so in addition to medical therapy, the patient developed a regime of physical therapy. Affected joints need to be developed, if the person doesn’t want to deal with disabilities.
From the corticosteroids Prednisolone, Dexamethasone, Hydrocortisone. Better rest proven cytostatic — Azathioprine, Cyclophosphamide, Methotrexate. If there is renal failure are shown hemodialysis, plasmapheresis and Hammarby. As a Supplement can be prescribed medications from a number of diuretics, anticoagulants and antiplatelet agents.
Systemic lupus erythematosus require hospitalization, only after intensive therapy, the patient can go home for outpatient treatment. If you are diagnosed with a disease, such as systemic lupus erythematosus treatment will be lengthy, it should mentally prepare. If you strictly adhere to medical recommendations, then the probability that you will live another 10-25 years, are quite high.
Complications of the disease
Mention why people die with lupus, I would like to mention that death comes not from the disease itself, but because of its consequences. To handle them is not always a virtue for doctors. Among the most serious complications, which inevitably lead to death include:
- heart attack and stroke;
- acute renal failure;
- liver failure;
- pulmonary embolism;
- gangrene of the intestine;
- thrombosis of the lower extremities;
- internal bleeding.
These pathological conditions are dangerous by themselves, but if they are supplemented with several inflammations of organs and malfunctions in other systems, the prognosis is unfavorable, in any case.
Unlike other diseases that people can prevent lupus erythematosus or as it sounds in Latin — lupus erythematodes — is a system pathologies that occur at the cellular level, and are closely associated with genetic disposition. Of course, to protect yourself, you can try to improve your immune power and taking the correct way of life, but it’s also not always helps to avoid autoimmune pathology.